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Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
Published on: May 27, 2022
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Effect of cannabidiolic acid and ∆
Erin M Rock1, Cheryl L Limebeer1, Linda A Parker2
1Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G2W1, Canada.
Psychopharmacology
|September 19, 2018
Summary
Cannabidiolic acid (CBDA) and Δ9-tetrahydrocannabinol (THC) demonstrate anti-inflammatory and anti-hyperalgesia properties in a rodent model. Combining low doses of CBDA and THC enhances these therapeutic effects.
Area of Science:
- Pharmacology
- Pain Management
- Inflammation Research
Background:
- Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are known for their anti-inflammatory and anti-hyperalgesia effects.
- Cannabidiolic acid (CBDA) is the acidic precursor to CBD and its therapeutic potential is under investigation.
Purpose of the Study:
- To evaluate the anti-inflammatory and anti-hyperalgesia effects of CBDA.
- To assess the mechanisms of action for CBDA and THC.
- To compare the efficacy of CBDA and CBD.
Main Methods:
- A rodent model of carrageenan-induced acute inflammation in the rat hind paw was utilized.
- CBDA and THC were administered systemically (intraperitoneal) or orally.
- Receptor antagonists were used to elucidate mechanisms of action.
Main Results:
- CBDA administered before carrageenan showed dose-dependent anti-hyperalgesia and anti-inflammatory effects.
- Both CBDA and THC demonstrated anti-hyperalgesia effects when given orally prior to carrageenan.
- CBDA's anti-hyperalgesia effects were mediated via TRPV1, while THC's effects involved CB1 receptors.
- CBDA was found to be more potent than CBD in reducing hyperalgesia.
- A combination of ineffective doses of CBDA and THC produced significant anti-hyperalgesia and anti-inflammatory effects.
Conclusions:
- CBDA and THC exhibit significant anti-inflammatory and anti-hyperalgesia effects in an acute inflammation model.
- CBDA demonstrates greater potency than CBD for hyperalgesia relief.
- Combined low doses of CBDA and THC offer a promising therapeutic strategy for inflammation and pain.
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