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Basement membrane and stroke.

Yao Yao1

  • 1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

The brain's basement membrane (BM) is crucial for blood-brain barrier (BBB) integrity. This review explores how BM changes after stroke and its role in neurological disorder pathogenesis.

Keywords:
Strokebasement membraneblood–brain barrierbrain ischemiaintracerebral hemorrhage

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • The basement membrane (BM) is a critical component at the interface of the circulation system and the central nervous system (CNS).
  • The BM plays a vital role in maintaining blood-brain barrier (BBB) integrity, which is essential for preventing neurological disorders.
  • Alterations in the BM are implicated in the pathogenesis of various neurological diseases, particularly stroke.

Purpose of the Study:

  • To review the composition and function of the brain's BM under homeostatic conditions.
  • To discuss the remodeling of the BM and its components after stroke (hemorrhagic and ischemic).
  • To elucidate the role of individual BM components in stroke pathogenesis and identify future research directions.

Main Methods:

  • Literature review of studies on brain BM composition and function.
  • Analysis of research on BM remodeling following stroke.
  • Synthesis of current knowledge on BM component roles in stroke pathogenesis.

Main Results:

  • The brain BM is composed of specific proteins that are vital for BBB maintenance.
  • Stroke induces significant remodeling of the BM, affecting its components.
  • The precise contribution of each BM component to stroke pathogenesis remains largely unclear.

Conclusions:

  • The BM is a key player in BBB regulation and stroke pathogenesis.
  • Further research is needed to understand the specific roles of BM components in stroke.
  • Future studies should focus on developing genetic tools to investigate BM/stroke interactions.