Related Experiment Video
Updated: Feb 5, 2026
03:46
Author Spotlight: Coproparasitoscopic Examination of Dog Stools for Control and Prevention of Zoonotic Parasite Diseases
Published on: December 15, 2023
4.2K
Praziquantel Resistance in the Zoonotic Cestode
Jeba Jesudoss Chelladurai1, Tsegabirhan Kifleyohannes2, Janelle Scott3
1Department of Veterinary Pathology, Iowa State University College of Veterinary Medicine, Ames, Iowa.
The American Journal of Tropical Medicine and Hygiene
|September 19, 2018
Summary
A new resistance to praziquantel in Dipylidium caninum (dog tapeworm) has emerged in dogs. This cestode infection is treatable with nitroscanate or a pyrantel/praziquantel/oxantel combination.
Area of Science:
- Veterinary Parasitology
- Molecular Biology
- Drug Resistance Studies
Background:
- Dipylidium caninum is a common tapeworm affecting companion animals and humans.
- Praziquantel is a primary anthelmintic for cestode infections, with no prior resistance reported.
- Limited alternative treatments exist for tapeworm infections in both human and veterinary medicine.
Observation:
- A cluster of canine cases infected with Dipylidium caninum showed resistance to praziquantel and epsiprantel between 2016 and 2018.
- Standard praziquantel treatment protocols, including increased dosage and frequency, were ineffective.
- Genetic characterization of resistant isolates involved sequencing of 28S, 12S, and voltage-gated calcium channel beta subunit genes.
Findings:
- Confirmed clinical resistance of Dipylidium caninum isolates to praziquantel.
- Successful treatment of resistant cases was achieved using nitroscanate or a compounded pyrantel/praziquantel/oxantel product.
- Identification of genetic markers associated with praziquantel resistance in D. caninum.
Implications:
- This discovery highlights an alarming emergence of anthelmintic resistance in a common veterinary parasite.
- Veterinarians and physicians must be aware of potential praziquantel treatment failures for D. caninum.
- Further research is needed to understand the mechanisms of resistance and to develop new therapeutic strategies.
Related Concept Videos
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:19Resistance
6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
01:16Equivalent Resistance
985
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
985
01:25Resistance and Conductance
517
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
517
01:21Rolling Resistance
665
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
665
01:20Vascular Resistance
11.0K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
11.0K