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Updated: Feb 5, 2026
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Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
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Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016
Emerging Infectious Diseases
|September 19, 2018
Summary
Maternal Zika virus infection during pregnancy can cause congenital defects. However, children born without birth defects showed no increased developmental delays in early childhood, warranting further research.
Area of Science:
- Neurology
- Infectious Diseases
- Developmental Pediatrics
Background:
- Congenital Zika virus syndrome encompasses a range of neurological issues in infants exposed in utero.
- The impact of prenatal Zika virus infection on neurocognitive development in children without birth defects remains largely uncharacterized.
Observation:
- A case-control study investigated the link between congenital defects and Zika virus infection.
- A nested study assessed early childhood development in children born without known birth defects to mothers with Zika virus infection.
Findings:
- Evidence suggests an association between congenital defects and maternal Zika virus seropositivity or symptomatic infection during pregnancy.
- No significant excess burden of developmental delay was observed in early childhood among children born without known birth defects to infected mothers.
Implications:
- Prenatal Zika virus infection is linked to congenital abnormalities.
- Further long-term studies are necessary to fully understand the neurodevelopmental outcomes in children exposed to Zika virus in utero, especially those without apparent birth defects.
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