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Protocol for a Randomised Controlled Trial Investigating Decompression for Leprous Neuropathy (The DELN Protocol)
Leprosy Review
|September 19, 2018
Summary
Nerve decompression shows promise for treating leprous neuropathy. An international randomized controlled trial (RCT) will evaluate its long-term effects on nerve function, pain, and disability in Hansen's Disease patients.
Area of Science:
- Neurology
- Immunology
- Surgical Research
Background:
- Leprosy, also known as Hansen's Disease, can cause debilitating neuropathic pain and disability.
- Nerve decompression is a potential treatment for nerve damage in leprosy patients.
Purpose of the Study:
- To evaluate the efficacy of nerve decompression in treating leprous neuropathy.
- To assess the long-term impact of nerve decompression on sensory and motor function, pain, disability, and quality of life.
Main Methods:
- An international, multi-center randomized controlled trial (RCT) protocol, Decompression for Leprous Neuropathy (DELN), has been designed.
- The DELN RCT will enroll patients with clinically diagnosed leprous neuropathy and positive Tinel signs.
- Patients will be randomized to receive either nerve decompression or no treatment.
Main Results:
- The study aims to determine the long-term effects of nerve decompression on key patient outcomes.
- Secondary outcomes include the prevention of ulcers, amputations, and the influence of corticosteroid therapy.
Conclusions:
- The DELN RCT has the potential to generate high-quality data on the effectiveness of nerve decompression for leprous neuropathy.
- Further discussion and collaboration within the peripheral nerve and leprosy communities are invited.
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