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Development of a Larval Zebrafish Infection Model for Clostridioides difficile
Published on: February 14, 2020
Advantage and issue of silkworm model for development of anti-infective agents
Abstract:
We established silkworm infection model for developing a novel antibiotic. Silkworm model has less ethical issues and is low cost compared to mammalian model, thus allow us to use a lot of individuals for screening assay. In addition, we can evaluate therapeutic activity and toxicity of candidate samples because silkworm has similar pharmacokinetics as mammals. Using this system, we identified a novel antibiotic named "Lysocin E". In this review article, we describe advantages of silkworm model for development of antimicrobial agents.
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