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Neural coding: A single neuron's perspective.

Alireza Azarfar1, Niccoló Calcini1, Chao Huang1

  • 1Department of Neurophysiology, Donders Institute for Brain, Cognition, and Behaviour Radboud University, the Netherlands.

Neuroscience and Biobehavioral Reviews
|September 19, 2018
PubMed
Summary
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Sensory neurons adapt their firing threshold to maintain information flow. This adaptive spike threshold controls how neurons communicate, ensuring accurate sensory representations in the brain.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Sensory Systems

Background:

  • Sensory neurons encode external stimuli through action potentials (spikes).
  • Information transfer relies on spatiotemporally correlated spiking patterns in neuronal populations.
  • Individual neuron spiking in the somatosensory cortex provides limited information about the external world.

Purpose of the Study:

  • To explain information flow from the sensory periphery to the primary sensory cortex.
  • To investigate the role of adaptive spike thresholds in neural information processing.
  • To elucidate how intracellular information transfer is regulated in somatosensory cortical neurons.

Main Methods:

  • Utilized a model sensory (whisker) system.
  • Analyzed principles of information transfer across synaptically coupled neurons.
Keywords:
Action potentialsInformation processingIntracellular information transferNeuronal representationsSomatosensory cortexSpike thresholdWhiskers

Related Experiment Videos

  • Examined the gating mechanism of adaptive spike thresholds.

    • Main Results:

    • Individual neuron spiking in the somatosensory cortex is minimally informative.
    • Neurons adapt their information transfer rate by adjusting the spike generation membrane potential.
    • Adaptive spike thresholds dynamically control intracellular information transfer.

    Conclusions:

    • Adaptive spike thresholds are crucial for counteracting information loss in sensory pathways.
    • This mechanism regulates the information content transmitted across somatosensory cortical neurons.
    • Understanding adaptive thresholds is key to deciphering neural coding and sensory representation.