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Updated: Feb 5, 2026
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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
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Regional white matter volume abnormalities in first-episode somatization disorder
Summary
Patients with somatization disorder (SD) show altered white matter volume (WMV) in specific brain regions. These WMV changes in the right inferior frontal gyrus and left inferior longitudinal fasciculus were not linked to clinical or cognitive factors.
Area of Science:
- Neuroimaging
- Psychiatry
- Neurology
Background:
- White matter integrity alterations are linked to somatization disorder (SD).
- Regional white matter volume (WMV) changes in SD patients are not well understood.
- This study investigates regional WMV in first-episode, drug-naive SD patients.
Purpose of the Study:
- To examine regional white matter volume (WMV) in patients with somatization disorder (SD).
- To explore relationships between WMV abnormalities and personality, cognition, and symptom severity in SD.
- To enhance understanding of SD pathophysiology through neuroimaging.
Main Methods:
- Recruited 25 first-episode, drug-naive SD patients and 28 healthy controls.
- Assessed personality traits, cognitive function, and symptom severity.
- Analyzed brain imaging data using Computational Anatomy Toolbox (CAT12).
Main Results:
- SD patients showed increased WMV in the right inferior frontal gyrus (IFG).
- SD patients exhibited decreased WMV in the left inferior longitudinal fasciculus (ILF).
- No significant correlations were found between abnormal WMV and clinical/cognitive variables.
Conclusions:
- Significant regional WMV abnormalities exist in first-episode, drug-naive SD patients.
- These findings contribute to understanding the neurobiological underpinnings of SD.
- Further research may elucidate the role of these WMV changes in SD pathophysiology.
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