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Updated: Aug 13, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Free radicals in skin exposed to dithranol and its derivatives
Abstract:
The generation of persistent free radical species derived from antipsoriatic drugs in their target tissue under use conditions is reported. Dithranol (anthralin, 1,8-dihydroxy-9-anthrone) and chemical analogues were applied topically to the ear of the pig and the time course of the production of the resulting free radicals was followed by electron spin resonance spectroscopy in biopsy samples. The spectral characteristics observed correspond to data previously reported in vitro for the anthralin-10-yl radical. The role of these radical species in the mode of action of the drug is discussed.
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