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Marathons and myasthenia gravis: a case report
Simone Birnbaum1,2,3, Tarek Sharshar4,5,6, Bruno Eymard7
1Institute of Myology, GH Pitié-Salpêtrière (AP-HP), Bd de l'Hôpital, 75651, Paris Cedex 13, France. s.birnbaum@institut-myologie.org.
BMC Neurology
|September 20, 2018
Summary
Individuals with myasthenia gravis can complete endurance events like marathons. Regular exercise may help manage symptoms and improve disease stability in patients with this autoimmune condition.
Area of Science:
- Neurology
- Exercise Physiology
- Autoimmune Diseases
Background:
- Autoimmune myasthenia gravis presents with fatigue and weakness, often leading patients to cease physical activity.
- Limited research exists on individuals with myasthenia gravis participating in regular endurance exercise.
Observation:
- A 36-year-old female with early myasthenia gravis symptoms continued long-distance running.
- Despite medical advice to stop sports, she pursued marathons for physical and mental well-being.
- She experienced fatigability but completed multiple marathons and achieved disease stability.
Findings:
- Endurance running, like marathons, can alter inflammatory mediators in a dose-dependent manner.
- Physical exertion is feasible in myasthenia gravis and may not exacerbate symptoms.
- Exercise might possess immunomodulatory effects, warranting further investigation.
Implications:
- This case suggests that adapted physical activity, including marathon running, can be compatible with myasthenia gravis.
- Further research with quantitative data is needed to confirm the immunomodulatory role of exercise in myasthenia gravis.
- Healthcare providers may reconsider advising complete cessation of sport for all myasthenia gravis patients.
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