Familial Anomalous Origin of Right Coronary Artery from the Left Coronary Sinus
Mohamed A Youniss1, Brian Ghoshhajra2, Samuel Bernard3
1Adult Congenital Heart Disease Program, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Insights
Familial clustering of coronary artery anomalies is rare. A father and son both experienced adverse cardiac events from anomalous origin of a coronary artery from the opposite sinus of Valsalva.
Area of Science:
- Cardiology
- Congenital Heart Disease
- Genetics
Background:
- Anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACOS) is a rare congenital heart defect.
- The familial occurrence of ACOS and its associated risks remain largely uncharacterized.
Observation:
- This report details a unique case involving a father and son.
- Both individuals presented with significant adverse cardiac events.
Findings:
- Both father and son were diagnosed with anomalous origin of the right coronary artery from the left coronary cusp.
- An interarterial course was noted in both cases, a high-risk anatomical feature.
Implications:
- This case highlights a potential genetic predisposition or familial clustering of ACOS.
- It underscores the importance of considering family history in patients diagnosed with coronary artery anomalies.
- Further research into the genetic basis of ACOS is warranted to understand familial risks.
Abstract:
Anomalous origin of a coronary artery from the opposite sinus of Valsalva is a rare congenital anomaly. The prevalence of familial clustering of coronary artery anomalies is unknown. Here we describe the case of a father and son, both of whom presented with major adverse cardiac events due to Anomalous origin of a coronary artery from the opposite sinus of Valsalva and both had right coronary artery arising from the left coronary cusp with an interarterial course.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease II: Pathophysiology
01:27Coronary Artery Disease V: Interprofessional Care
01:30Coronary Artery Disease III: Clinical Manifestations
01:26Coronary Artery Disease IV: Preventive Measures
01:21Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...