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Updated: Feb 5, 2026

Whole-Mount Immunofluorescence Staining, Confocal Imaging and 3D Reconstruction of the Sinoatrial and Atrioventricular Node in the Mouse
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Whole-Mount Immunofluorescence Staining, Confocal Imaging and 3D Reconstruction of the Sinoatrial and Atrioventricular Node in the Mouse

Published on: December 22, 2020

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Frequency and Significance of High-Degree Atrioventricular Block and Sinoatrial Node Dysfunction in Patients With

Naoki Misumida1, Gbolahan O Ogunbayo1, Sun Moon Kim1

  • 1Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY and VA Medical Center, Lexington, Kentucky.

The American Journal of Cardiology
|September 20, 2018
PubMed

Insights

Sinoatrial node dysfunction (SND) is more common after non-ST-elevation myocardial infarction (NSTEMI) than high-degree AV block (HDAVB). NSTEMI patients with HDAVB had higher mortality and pacemaker implantation rates compared to STEMI patients.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Conduction disorders post-STEMI are well-documented.
  • Limited data exist on conduction disorders following NSTEMI, including their incidence, treatment, and prognosis.

Purpose of the Study:

  • To compare the characteristics and outcomes of conduction disorders in STEMI versus NSTEMI patients.
  • To investigate treatment trends and prognostic impact of conduction disorders after NSTEMI.

Main Methods:

  • Utilized the National Inpatient Sample database (2010-2014).
  • Compared STEMI (135,468 patients) and NSTEMI (281,928 patients) cohorts.
  • Classified conduction disorders into high-degree AV block (HDAVB) and sinoatrial node dysfunction (SND).

Main Results:

  • SND was more frequent than HDAVB in NSTEMI (0.9% vs 0.6%), while HDAVB predominated in STEMI (2.4% vs 0.5%).
  • NSTEMI patients with HDAVB had higher permanent pacemaker implantation rates (30.0% vs 11.6%) and in-hospital mortality (16.6% vs 3.8%) than STEMI patients.
  • Pacemaker implantation rates for SND were similar between STEMI and NSTEMI cohorts (33.9% vs 30.5%).

Conclusions:

  • SND is more prevalent than HDAVB in NSTEMI, unlike STEMI where HDAVB is more common.
  • HDAVB after NSTEMI suggests lower spontaneous resolution rates and necessitates pacemaker implantation in about one-third of cases.
  • Conduction disorders, particularly HDAVB, portend a worse prognosis in NSTEMI patients.

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