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Related Experiment Video

Updated: Feb 5, 2026

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Bubble dynamics in boiling histotripsy.

Ki Joo Pahk1, Pierre Gélat2, Hyungmin Kim1

  • 1Center for Bionics, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Ultrasound in Medicine & Biology
|September 20, 2018
PubMed
Summary
This summary is machine-generated.

Boiling histotripsy uses ultrasound pulses to break down tissue. New acoustic features help monitor this mechanical fractionation and distinguish it from thermal ablation, improving treatment understanding.

Keywords:
boiling histotripsycavitation monitoringhigh intensity focused ultrasound

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Area of Science:

  • Acoustics
  • Biomedical Engineering
  • Ultrasound Technology

Background:

  • Boiling histotripsy is a non-invasive ultrasound technique for mechanical tissue fractionation.
  • Current treatment monitoring relies on limited understanding of bubble dynamics during boiling histotripsy.
  • Distinguishing between thermal and mechanical ablation effects via cavitation measurement is challenging.

Purpose of the Study:

  • Extract qualitative and quantitative features of bubbles induced by shockwaves.
  • Differentiate cavitation activity between thermal and mechanical liver lesions.
  • Develop a numerical model to simulate bubble dynamics under ultrasound exposure.

Main Methods:

  • Developed a numerical bubble model based on the Gilmore equation, incorporating heat and mass transfer.
  • Investigated bubble dynamics in tissue exposed to High Intensity Focused Ultrasound (HIFU) with varying temperatures.
  • Conducted ex vivo liver experiments using a passive cavitation detection system to record acoustic emissions.

Main Results:

  • Numerical simulations identified shockwave asymmetry and water vapor transport as key factors for bubble growth at 100°C.
  • Rectified bubble motion onset correlated with increased radiated pressure and appearance of higher-order harmonics.
  • Boiling histotripsy produced higher-order harmonics and broadband emissions compared to thermal ablation, consistent with experimental data.

Conclusions:

  • Unique acoustic features, including higher-order harmonics and broadband emissions, can monitor boiling histotripsy.
  • These features allow differentiation between mechanical fractionation and thermal ablation cavitation.
  • Acoustic monitoring can detect the formation of boiling bubbles during HIFU exposure.