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Catalytically Perfect Enzymes01:07

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The theory of catalytically perfect enzymes was first proposed by W.J. Albery and J. R. Knowles in 1976. These enzymes catalyze biochemical reactions at high-speed. Their catalytic efficiency values range from 108-109 M-1s-1. These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. Examples include triose phosphate isomerase, fumarase, and superoxide dismutase.
 
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Single Port Donor Nephrectomy
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Donor-funded research: permissible, not perfect.

Mike King1, Angela Ballantyne1,2

  • 1Bioethics Centre, School of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand.

Journal of Medical Ethics
|September 20, 2018
PubMed
Summary

Donor-funded research, often called "pay to play," can be ethical. This research, when regulated and reviewed, offers benefits for health research and personal liberty.

Keywords:
clinical trialsdrugs and drug industryethics committees/consultationresearch ethicsresearch on special populations

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Area of Science:

  • Medical Ethics
  • Health Research Funding

Background:

  • Donor-funded research involves private funding for research benefits.
  • Criticized as unethical, termed 'pay to play' research.

Purpose of the Study:

  • To outline and argue for the permissibility of donor-funded research models.
  • To address ethical objections concerning exploitation and fairness.

Main Methods:

  • Analysis of three donor-funded research models.
  • Ethical argumentation based on personal liberty and research facilitation.
  • Defense against counterarguments regarding fairness and public good.

Main Results:

  • Donor-funded research can be permissible under specific ethical frameworks.
  • It can facilitate otherwise unfunded health research.
  • Consistency with existing ethical standards for human subjects research is possible.

Conclusions:

  • Donor-funded research should be regulated by standard health research legislation and undergo ethical/peer review.
  • Acceptability of such research depends on adherence to established review standards.