Variations of cingulate sulcal organization and link with cognitive performance
Céline Amiez1, Charles R E Wilson2, Emmanuel Procyk2
1Univ Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500, Bron, France. celine.amiez@inserm.fr.
Scientific Reports
|September 20, 2018
Summary
The sulcal morphology of the medial frontal cortex shows significant left-right laterality. Environmental factors, particularly prenatal, play a larger role than genetics in shaping paracingulate sulcus development.
Area of Science:
- Neuroscience
- Human Anatomy
- Developmental Biology
Background:
- Sulcal morphology in the human medial frontal cortex is linked to function and associated with psychiatric disorders and cognitive traits.
- Limited understanding exists regarding the genetic and environmental influences on the development of medial frontal cortex sulcal patterns.
Purpose of the Study:
- To investigate the genetic and environmental factors influencing the ontogenesis of sulcal morphology in the human medial frontal cortex.
- To examine hemispheric biases and heritability of paracingulate sulci.
- To explore the relationship between sulcal organization and cognitive, motor, and affective performance in relation to twin status.
Main Methods:
- Analysis of sulcal morphology in 599 subjects from the Human Connectome Project, including twins, non-twin siblings, and controls.
- Statistical analysis to assess hemispheric biases in paracingulate sulci presence.
- Heritability estimations and similarity measures between siblings to infer genetic and environmental influences.
- Correlation analysis between sulcal organization and performance on cognitive, motor, and affective tests, stratified by twin status.
Main Results:
- Confirmed significant left-hemisphere bias in the presence of paracingulate sulci across the population.
- Heritability estimates indicated weak additive genetic factors and significant environmental influences, especially in-womb environment, on paracingulate sulcus development.
- Relationships between medial frontal cortex sulcal organization and performance varied depending on twin status.
Conclusions:
- Sulcal organization in the human medial frontal cortex exhibits significant laterality.
- Environmental factors, particularly prenatal, are more influential than additive genetics in shaping paracingulate sulcus presence.
- The association between medial frontal cortex sulcal patterns and behavioral/cognitive performance is modulated by genetic relatedness (twin status).
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