Related Experiment Video
Updated: Feb 5, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
Published on: October 31, 2007
Glucocorticoids and Diabetes
Kevin T Bauerle1, Charles Harris2
1Kevin T. Bauerle, MD, PhD, is a Clinical Fellow, Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis.
Abstract:
Glucocorticoids (GCs), stress hormones produced by the adrenal gland, are involved in many pathways in physiology and metabolism including glucose homeostasis and inflammation. Excess GC signaling results in Cushing's syndrome and possibly metabolic syndrome. Diabetes, central adiposity, and hyperlipidemia are components of both syndromes. Here, we discuss the mechanisms of GC action, clinical syndromes of GC excess, modulation of glucose homeostasis by GCs, and future treatments for diabetes based on GC signaling.
Related Concept Videos
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Psychoneuroimmunology: Diabetes and Cancer
Diabetes Mellitus: Type 2 and Gestational

