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Updated: Feb 5, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
Published on: July 5, 2010
Evaluating Soft-Tissue Lumps and Bumps
Dane J Church1, John Krumme2, Suhel Kotwal3
1Dane J. Church, MD, is a Chief Resident, MSMA member since 2010, is a Senior Resident in the Department of Orthopaedic Surgery at the University of Missouri - Kansas City School of Medicine.
Abstract:
Patients presenting with soft-tissue lumps and bumps are commonly encountered by both primary care physicians and orthopaedic surgeons. Though common, the initial evaluation and management of a soft-tissue mass can be challenging for many clinicians due to the considerable overlap in the presentation of benign and malignant tumors. Furthermore, a myriad of conditions, ranging from infection to trauma, can present with a soft-tissue mass. Subsequently, the correct diagnosis is often delayed or missed which may ultimately lead to inappropriate treatment. The propose of this article is to review the fundamental elements of a successful soft-tissue mass work-up and to provide the clinician with a systematic approach to the evaluation, diagnosis and management of the patient with a soft-tissue tumor.
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