Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.

M D Chafetz, K Parko, S Diaz

    Brain Research
    |October 8, 1986
    PubMed
    Summary

    Hypoglycemia reduces alpha 2-receptor binding in the hypothalamus, impacting feeding behaviors. Glucose levels directly correlate with this binding, suggesting a hypothalamic glucose homeostasis system.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

    Physical review letters·2024
    Same author

    Integrated full-scale solar CPC/UV-LED-filtration system as a tertiary treatment in a conventional WWTP for agricultural reuse purposes.

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2022
    Same author

    Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.

    International journal of transgender health·2022
    Same author

    Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

    Physical review letters·2022
    Same author

    Does exposure to greenness improve children's neuropsychological development and mental health? A Navigation Guide systematic review of observational evidence for associations.

    Environmental research·2021
    Same author

    Global plant trait relationships extend to the climatic extremes of the tundra biome.

    Nature communications·2020

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Metabolic Regulation

    Background:

    • The medial hypothalamus plays a crucial role in regulating feeding behavior and energy balance.
    • Alpha 2-adrenergic receptors are implicated in various physiological processes, including appetite control.
    • Circulating glucose levels are known to influence brain function and neurochemical signaling.

    Purpose of the Study:

    • To investigate the relationship between circulating glucose availability and alpha 2-receptor binding in the medial hypothalamus.
    • To determine if changes in glucose levels affect the density or affinity of alpha 2-receptors.
    • To explore the role of the hypothalamic feeding system in glucose homeostasis.

    Main Methods:

    • Utilized food deprivation and tolbutamide-induced hypoglycemia models in experimental subjects.

    Related Experiment Videos

  • Quantified medial hypothalamic alpha 2-receptor binding using radioligand binding assays.
  • Measured serum glucose levels and observed the effects of dextrose and norepinephrine administration.

    • Main Results:

    • Both food deprivation and tolbutamide-induced hypoglycemia significantly decreased medial hypothalamic alpha 2-receptor binding.
    • Alpha 2-receptor binding levels showed a strong positive correlation with serum glucose concentrations.
    • Concomitant dextrose administration prevented the reduction in alpha 2-binding caused by hypoglycemia; norepinephrine injection increased serum glucose.

    Conclusions:

    • Medial hypothalamic alpha 2-receptor availability is dependent on circulating glucose levels.
    • These findings suggest a homeostatic mechanism within the hypothalamus for regulating glucose.
    • The hypothalamic feeding system appears to be integrated with glucose metabolism control.