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Fatigue and its associated factors in microscopic colitis
John S Kane1, Andrew J Irvine2, Yannick Derwa2
1Leeds Gastroenterology Institute, 4 Floor, Bexley Wing, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
Therapeutic Advances in Gastroenterology
|September 20, 2018
Summary
Fatigue in microscopic colitis (MC) is linked to irritable bowel syndrome (IBS)-type symptoms and psychological distress. Addressing these factors may improve patient quality of life and fatigue management in MC.
Area of Science:
- Gastroenterology
- Psychology
- Quality of Life Research
Background:
- Fatigue is common in inflammatory bowel disease and irritable bowel syndrome (IBS).
- Features of fatigue in microscopic colitis (MC) are not well understood.
- Psychological comorbidity and impaired quality of life are associated with fatigue in other gastrointestinal conditions.
Purpose of the Study:
- To investigate the characteristics and associations of fatigue in patients with newly diagnosed microscopic colitis (MC).
- To assess the impact of psychological factors and IBS-type symptoms on fatigue in MC patients.
- To correlate fatigue levels with anxiety, depression, somatization, and quality of life.
Main Methods:
- A cross-sectional survey was conducted on 129 patients with newly diagnosed MC.
- Patients completed questionnaires assessing fatigue (using the Inflammatory Bowel Disease Fatigue self-assessment scale), anxiety, depression, somatization, quality of life, and IBS-type symptoms.
- Mean fatigue scores were compared with patient characteristics and correlated with psychological and quality-of-life measures.
Main Results:
- Higher fatigue severity and impact scores were associated with IBS-type symptoms, anxiety, depression, and somatization (p < 0.0001).
- Significant positive correlations were found between fatigue and anxiety, depression, and somatization scores (p < 0.001).
- Significant negative correlations were observed between fatigue and quality-of-life measures (p < 0.001).
Conclusions:
- Fatigue in microscopic colitis is associated with IBS-type symptoms and psychological comorbidity.
- Impaired quality of life is also linked to fatigue in MC patients.
- Targeting IBS-type symptoms and psychological factors may be crucial for managing fatigue in MC.
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