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Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis
Katharina Staufer1,2, Emina Halilbasic2, Peter Hillebrand2
1Department of Surgery, Division of Transplantation, Medical University of Vienna, Vienna, Austria.
Background:
Nutritional status is an important prognostic factor in patients with cystic fibrosis (CF) prior to lung transplantation.
Objective:
To investigate the impact of nutritional status on pulmonary function in CF transplant recipients.
Methods:
Adult double lung transplanted CF patients were consecutively included. The predictive value of nutritional status on lung function - measured by spirometry - was longitudinally assessed by body composition serially evaluated by a three-compartment model bioelectrical impedance analysis (BIA) in comparison to body mass index (BMI).
Results:
Overall, 147 spirometries and 147 BIAs were performed in 58 patients (59% female, median age: 30.1 years, median BMI: 19.6 kg/m2). Malnourished patients (BMI < 18.5 kg/m2; 27.6%) had a significantly reduced lung function compared to normal/overweight patients (forced expiratory volume in 1 second in percent (FEV1%pred), 57% vs 77%; p = 0.024). BMI, as well as the BIA parameters phase angle, total body water, fat free mass, body cell mass (BCM) and extracellular mass (ECM)/BCM ratio, were univariate predictors of FEV1%pred. When included in a linear mixed model, ECM/BCM ratio remained the only significant predictor of lung function (p = 0.012).
Conclusion:
Nutritional status assessed by BIA predicted lung function in CF transplant recipients. Serial BIA measurements to monitor patients' nutritional status might help to improve or maintain lung function.
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