New Advances in Toxicological Forensic Analysis Using Mass Spectrometry Techniques.

Area of Science:

• Forensic toxicology
• Analytical chemistry
• Pharmacology

Background:

• Accurate identification and quantification of drugs of abuse are critical in forensic toxicology.
• Mass spectrometry (MS) is a cornerstone technology in this field.
• Advancements in MS have continually improved analytical capabilities.

Purpose of the Study:

• To review current mass spectrometry methods for drug analysis in forensic toxicology.
• To discuss emerging screening and targeted analysis methodologies.
• To explore the evolution of mass spectrometry instrumentation relevant to forensic applications.

Main Methods:

• Review of literature on mass spectrometry techniques.
• Focus on methodologies for identifying and quantifying drugs in biological samples (fluids, tissues) and synthetic matrices.
• Discussion of common and novel MS approaches.

Main Results:

• Mass spectrometry is essential for drug identification and quantification in forensic toxicology.
• Established MS methods are widely used, with new techniques offering enhanced sensitivity and specificity.
• Instrumentation has evolved significantly, improving speed and detection limits.

Conclusions:

• Mass spectrometry remains a vital tool in forensic toxicology.
• Ongoing developments in MS methodologies and instrumentation continue to advance drug analysis capabilities.
• The field benefits from continuous innovation in analytical techniques.