Related Experiment Video

Updated: Feb 5, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K

Antithrombotic therapy in ventricular assist device (VAD) management: From ancient beliefs to updated evidence. A

Nuccia Morici1,2, Marisa Varrenti3, Dario Brunelli1,4

  • 1Intensive Cardiac Care Unit and De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

International Journal of Cardiology. Heart & Vasculature
|September 20, 2018
PubMed

Insights

Antiplatelet drugs are crucial for managing ventricular assist device (VAD) thrombosis. Current strategies face challenges with bleeding and clotting, necessitating optimized antithrombotic regimens for VAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biomedical Engineering

Background:

  • Platelets are central to ventricular assist device (VAD) thrombosis.
  • Antiplatelet therapy is vital for acute and long-term VAD management.
  • Aspirin is the standard lifelong treatment post-VAD implantation.

Purpose of the Study:

  • To review evidence on antithrombotic strategies for VAD patients.
  • To explore pathophysiologic mechanisms of bleeding and thrombosis in VADs.
  • To identify optimal pharmacological management for VAD-associated thrombotic and bleeding events.

Main Methods:

  • Review of randomized clinical trials.
  • Analysis of observational studies.
  • Focus on pathophysiologic mechanisms of VAD thrombosis and bleeding.

Main Results:

  • Bleeding and thrombotic events remain frequent in VAD patients.
  • Dual antiplatelet therapy increases bleeding risk.
  • Uniform strategies for VAD antithrombotic management are lacking.

Conclusions:

  • Optimizing antithrombotic regimens is critical for VAD patient outcomes.
  • Further research is needed to establish standardized VAD management protocols.
  • Balancing antithrombotic efficacy and bleeding risk remains a key challenge.

Keywords:
AnticoagulationAntiplatelet therapyAntithrombotic managementAssist deviceBleedingThrombosis

More Related Videos

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.1K
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.9K

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.3K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
748
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
446