Related Experiment Video
Updated: Aug 18, 2026

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Cytotoxic T-lymphocyte recognition of simian virus 40 antigens
Abstract:
During the transformation of mammalian cells by SV40, the cells acquire new antigenicity at the cell surface that acts as a target for cytotoxic T lymphocytes. Evidence is discussed which leads to the conclusion that the product of the SV40 tsA gene, the T antigen, is directly involved in converting a cell to malignant phenotype, is largely localized in the nucleus of transformed cells and is also present at the cell surface. Therefore, it appears that the T antigen serves a dual function, i.e. it is involved in the initiation and maintenance of transformation and provides a target for the immune effector mechanisms in the host undergoing viral carcinogenesis.
More Related Videos
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
10:13Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
Related Concept Videos
Mechanisms of Retrovirus-induced Cancers
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytomegalovirus Disease