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Updated: Feb 5, 2026

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Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
Published on: June 30, 2017
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Progress in achieving quantitative classification of psychopathology
Robert F Krueger1, Roman Kotov2, David Watson3
1Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Summary
Quantitative approaches reveal psychopathology is dimensional and hierarchical, not categorical. The Hierarchical Taxonomy of Psychopathology (HiTOP) offers a data-driven classification system for improved clinical utility.
Area of Science:
- Psychiatry
- Psychology
- Data Science
Background:
- Traditional expert-based classification systems for psychopathology have limitations.
- Contemporary research emphasizes quantitative and empirical methods for classification.
Purpose of the Study:
- To review progress in developing a quantitative, empirical classification of psychopathology.
- To introduce the Hierarchical Taxonomy of Psychopathology (HiTOP) Consortium and its objectives.
Main Methods:
- Review of substantial empirical literature on psychopathology's structure.
- Analysis of evidence supporting dimensional and hierarchical models over categorical ones.
- Examination of the utility of empirically derived constructs.
Main Results:
- Evidence strongly supports a dimensional, rather than categorical, view of psychopathology.
- Psychopathology dimensions can be organized hierarchically, from broad to specific symptom clusters.
- This quantitative approach addresses the problem of comorbidity by modeling co-occurrence patterns.
Conclusions:
- The dimensional and hierarchical structure of psychopathology is well-supported by empirical evidence.
- The Hierarchical Taxonomy of Psychopathology (HiTOP) provides a clinically useful, empirically-based framework.
- The HiTOP Consortium aims to advance research, clinical utility, and assessment tools for psychopathology.
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