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A single dose of beetroot juice improves endothelial function but not tissue oxygenation in pregnant women: a

Mônica Volino-Souza1, Gustavo Vieira de Oliveira1, Thiago Silveira Alvares1

  • 1Nutrition and Exercise Metabolism Research Group,Nutrition Institute,Universidade Federal do Rio de Janeiro,Macaé, 27979-000 Rio de Janeiro,Brazil.

The British Journal of Nutrition
|September 20, 2018
PubMed

Beetroot juice (BJ) consumption has been associated with improved cardiovascular health owing to an increase in NO bioconversion. This study evaluates the effect of BJ consumption on macrovascular endothelial function (flow-mediated dilation (FMD)) and muscle oxygen saturation (StO2) parameters in pregnant women within a randomised, crossover, double-blind design in which twelve pregnant women consumed a single dose (140 ml) of BJ or placebo (PLA). Urinary nitrate was assessed before (T0) and 150 min after BJ/PLA consumption. FMD was used to evaluate macrovascular endothelial function, and near-IR spectroscopy was used to evaluate muscle StO2 parameters during the occlusion and reperfusion phases, which were taken at baseline (PRE) and 120 and 140 min after BJ/PLA consumption, respectively. A significant increase in urinary nitrate was observed at 150 min after BJ consumption when compared with T0 (BJ: 0·20 (sd 0·13) v. T0: 0·02 (sd 0·00), P=0·000) and PLA intervention (PLA: 0·02 (sd 0·00), P=0·001). FMD improved after BJ consumption when compared with PRE (BJ: 11·00 (sd 1·67) v. PRE: 5·53 (sd 1·17), P=0·000) and PLA (5·34 (sd 1·31), P=0·000). No significant difference between PLA and PRE in FMD (P=1·000) was observed. In StO2 parameters, a difference was not observed after BJ consumption compared with PRE and PLA intervention. The data demonstrate that a single dose of 140 ml of BJ consumption improves macrovascular endothelial function, but not StO2 parameters.

Keywords:
BJ beetroot juiceFGR fetal growth restrictionFMD flow-mediated dilatationGDM gestational diabetes mellitusNIRS near-IR spectroscopyPLA placeboPRE baselineStO2 base baseline oxygen saturationStO2 max maximal oxygen saturationStO2 min minimum oxygen saturationStO2 oxygen saturationStO2 slope_1 desaturation rateStO2 slope_2 resaturation rateStO2 tmax time to maximal oxygen saturationDietary nitrateFunctional foodMicrocirculationPregnancyVascular function

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