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Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Published on: July 4, 2016
EPR sensing of metal and organic cations using a novel spin-labelled dibenzo-24-crown-8-ether
Lorenzo Gualandi1, Paola Franchi, Alberto Credi
1Dipartimento di Chimica "G. Ciamician", University of Bologna, Via San Giacomo 11, 40126, Bologna, Italy. marco.lucarini@unibo.it.
Abstract:
The synthesis of novel dibenzo-24-crown ether substituted nitroxides and their use as spin probes for the detection of cation guests by EPR are reported. Formation of a host-guest complex between the proposed spin probes and several cations, both organic and inorganic, was evidenced by a significant change in the value of the benzylic and nitrogen EPR hyperfine splittings upon complexation. This favorable feature provided a reliable EPR sensor that is able to selectively distinguish different cationic guests.
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