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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Chronic Obstructive Pulmonary Disease01:24

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Related Experiment Video

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Potassium control in chronic kidney disease: implications for neuromuscular function.

Ria Arnold1, Timothy J Pianta2, Bruce A Pussell3,4

  • 1School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.

Internal Medicine Journal
|September 20, 2018
PubMed
Summary

Chronic kidney disease (CKD) is linked to a high prevalence of peripheral neuropathy, even in early stages. Managing potassium levels may improve nerve function and reduce complications in CKD patients.

Keywords:
chronic kidney diseasefoot complicationperipheral neuropathypotassiumtreatment

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Area of Science:

  • Nephrology
  • Neurology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) affects 1.7 million Australian adults.
  • Hyperkalemia is a common complication of CKD.
  • Peripheral neuropathy is an under-recognized complication of CKD, contributing to significant morbidity.

Purpose of the Study:

  • To review the evidence linking potassium levels and peripheral neuropathy in CKD.
  • To discuss the clinical implications of this relationship.
  • To highlight the need for increased awareness and targeted treatment strategies.

Main Methods:

  • Literature search of PubMed using pre-specified keywords.
  • Inclusion of original articles, review articles, clinical guidelines, and population data.

Main Results:

  • Peripheral neuropathy is highly prevalent in CKD patients, including those with stage 3-4 CKD and without diabetes.
  • Foot complications and amputation rates are rising in dialysis patients.
  • Potassium's role in nerve function is established in dialysis patients, and early CKD research suggests potassium control may benefit neuromuscular outcomes.

Conclusions:

  • Peripheral neuropathy is a significant complication of CKD with multifactorial causes.
  • Assertive potassium management may improve neuromuscular outcomes in CKD.
  • Further large-scale, multicenter studies are needed to confirm these findings.