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Updated: Feb 5, 2026

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

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Published on: March 17, 2023

Bioengineering Organs for Blood Detoxification.

Cécile Legallais¹, Dooli Kim², Sylvia M Mihaila^3,4

¹UMR CNRS 7338 Biomechanics & Bioengineering, Université de technologie de Compiègne, Sorbonne Universités, 60203, Compiègne, France.

Advanced Healthcare Materials

|September 20, 2018

Summary

This summary is machine-generated.

Organ transplantation is ideal for severe kidney or liver failure, but bioengineered organs offer a promising alternative. This review explores artificial and bioartificial devices, aiming to restore full organ function for patients ineligible for transplants.

Keywords:

bioengineered organs blood detoxification kidneys livers

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Organoid Technology

Background:

Severe kidney and liver failure necessitate organ transplantation, but limited availability and patient ineligibility restrict treatment options.
Current artificial kidney and liver devices partially restore organ function but cannot fully replicate complex cellular processes.
Bioengineered organs aim to emulate native kidney and liver functions through cellular engineering and scaffold-based approaches.

Purpose of the Study:

To review current advancements in bioengineered kidney and liver organs.
To compare artificial, bioartificial, and biohybrid organ constructs.
To discuss the clinical applicability and future perspectives of these regenerative therapies.

Main Methods:

Literature review of artificial kidney/liver devices, bioartificial kidney/liver devices, and biohybrid constructs.
Analysis of cellular culture techniques on perfusable scaffolds.
Examination of decellularization and recellularization strategies for organ regeneration.

Main Results:

Artificial devices offer partial support but have functional limitations.
Bioartificial devices show potential for improved functional replacement.
Biohybrid approaches using decellularized/recellularized organs present novel regenerative strategies.

Conclusions:

Bioengineered organs hold significant promise for treating kidney and liver failure.
Further research is needed to overcome current limitations and achieve full clinical integration.
Regenerative medicine approaches are crucial for advancing organ replacement therapies.