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Experimental Methods of Dust Charging and Mobilization on Surfaces with Exposure to Ultraviolet Radiation or Plasmas
Published on: April 3, 2018
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Particulate metal exposures induce plasma metabolome changes in a commuter panel study
Chandresh Nanji Ladva1, Rachel Golan2, Donghai Liang3
1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States of America.
Plos One
|September 20, 2018
Summary
Traffic pollution alters metabolism, impacting inflammatory and metabolic pathways. This study used high-resolution metabolomics to link car commute air pollution to changes in biomarkers and metabolites.
Area of Science:
- Environmental Health Sciences
- Metabolomics
- Toxicology
Background:
- Advances in liquid chromatography-mass spectrometry (LC-MS) enable high-resolution metabolomics (HRM).
- HRM is a sensitive tool for measuring environmental exposures and biological responses.
- On-road traffic exposures can lead to metabolic perturbations.
Purpose of the Study:
- To examine in-vehicle air pollution concentrations, inflammatory biomarker levels, and metabolomic profiles.
- To trace potential metabolic perturbations associated with on-road traffic exposures in car commuters.
Main Methods:
- A 60-person panel study involving highway and side-street commutes.
- Analysis of pre- and post-exposure dried blood spots for biomarkers and plasma metabolome.
- Utilized LC-MS, R software (apLCMS, xMSanalyzer, limma), and mummichog for data processing, analysis, and annotation.
Main Results:
- HRM detected 110 metabolic features perturbed by particulate metal exposures (Al, Pb, Fe).
- Changes in arachidonic acid, leukotriene, and tryptophan metabolism were observed.
- Two-hour changes in proinflammatory biomarkers correlated with 10-hour plasma metabolome changes, indicating amino acid, leukotriene, and antioxidant metabolism effects.
Conclusions:
- Acute exposure to traffic-related air pollutants is linked to a broad inflammatory response.
- Specific metabolites like 20-OH-LTB4 decreased, suggesting a subclinical immune response to particulate metal exposure.
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