Related Experiment Video
Updated: Feb 5, 2026
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
11.2K
Practical Methods for Integrating Genetic Testing Into Clinical Practice for Advanced Prostate Cancer
Heather Cheng1, Jacquelyn Powers1, Kerry Schaffer1
1From the University of Washington, Seattle, WA; University of Pennsylvania, Philadelphia, PA; University of Rochester, Rochester, NY; Tulane Cancer Center, New Orleans, LA.
Summary
Germline genetic testing and somatic genomic profiling offer new options for advanced prostate cancer. This guide clarifies genetic testing for patients and providers, addressing current uncertainties.
Area of Science:
- Oncology
- Genetics
- Clinical Medicine
Background:
- Germline genetic testing and somatic genomic profiling are increasingly relevant in advanced prostate cancer.
- Identifying genetic mutations can reveal therapeutic options and clinical trial eligibility.
- Genetic findings have implications for family members and patient healthcare management.
Purpose of the Study:
- To provide a practical overview of recent advances in genetic testing for prostate cancer.
- To discuss options and considerations for germline and somatic testing.
- To offer guidance for healthcare providers and patients regarding genetic testing.
Main Methods:
- Review of recent scientific literature and clinical guidelines.
- Discussion of practical considerations for offering genetic testing services.
- Identification of key discussion points for patient-provider communication.
Main Results:
- Genetic testing can identify actionable therapeutic and clinical trial options in advanced prostate cancer.
- Germline mutations have significant implications for family members and patient management.
- There is ongoing debate regarding the optimal approach to offering genetic testing.
Conclusions:
- Genetic testing offers significant potential benefits but requires careful consideration of various factors.
- Clear guidance is needed for providers and patients to navigate the complexities of genetic testing.
- Resources are available to support informed decision-making in genetic testing for prostate cancer.
Related Concept Videos
01:16Characteristics of Practical Op Amps
869
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
869
01:30Theoretical Foundations of Nursing Practice
17.5K
Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
17.5K
01:28Equivalent Circuits for Practical Transformers
1.4K
The practical equivalent circuits of single-phase two-winding transformers exhibit significant deviations from their idealized versions due to the inherent properties of winding resistance and finite core permeability. These properties result in real and reactive power losses, affecting the transformer's performance. Understanding these deviations is crucial for designing more efficient transformers.
In a practical transformer, each winding exhibits resistance and leakage reactance. The...
In a practical transformer, each winding exhibits resistance and leakage reactance. The...
1.4K
00:56Extraction: Advanced Methods
1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
01:27Myocarditis II: Clinical Features and Diagnostic Tests
323
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
323
01:19Pericarditis II: Clinical Features and Diagnostic Tests
329
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
329