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Evolution of Targeted Therapy in Breast Cancer: Where Precision Medicine Began

Jane Lowe Meisel1, Vyshak Alva Venur1, Michael Gnant1

  • 1From the Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA; University of Iowa, Iowa City, IA; Medical University of Vienna and Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting
|September 21, 2018
PubMed

Insights

Breast cancer targeted therapies, like anti-estrogen and anti-HER2 treatments, offer insights into overcoming treatment resistance. Ongoing research explores new strategies for endocrine and HER2-directed therapy resistance.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Estrogen receptor-positive and HER2-positive breast cancer have been studied for decades.
  • Targeted therapies have revolutionized breast cancer treatment.
  • Understanding resistance mechanisms is crucial for improving patient outcomes.

Purpose of the Study:

  • To review the historical development of anti-estrogen and anti-HER2 therapies.
  • To discuss the evolving understanding of resistance to these targeted treatments.
  • To highlight recent breakthroughs and ongoing research in overcoming therapy resistance.

Main Methods:

  • Literature review of anti-estrogen and anti-HER2 therapy development.
  • Analysis of resistance mechanisms in endocrine and HER2-directed therapies.
  • Synthesis of current research findings and future directions.

Main Results:

  • Established a historical context for targeted breast cancer therapies.
  • Detailed the progression of understanding treatment resistance.
  • Identified key breakthroughs in overcoming resistance to endocrine and anti-HER2 treatments.

Conclusions:

  • Breast cancer serves as a valuable model for studying targeted therapy resistance.
  • Continued research is essential for advancing endocrine and anti-HER2 therapy efficacy.
  • Improved understanding of resistance mechanisms will guide future clinical trial design and treatment strategies.

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