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Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments
Amit Ranjan1, Anna Dongari-Bagtzoglou2
1Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030, USA. aranjan@uchc.edu.
Journal of Fungi (Basel, Switzerland)
|September 21, 2018
Summary
Resident bacteria can either inhibit or promote Candida albicans infections. Understanding these complex interactions is crucial for developing new treatments for mucosal candidiasis, especially in vulnerable patients.
Area of Science:
- Microbiology
- Mycology
- Immunocompromised Host Research
Background:
- Candida albicans is a fungus found on mucosal and skin sites.
- It is a significant cause of infection in immunocompromised individuals.
- Resident bacteria were traditionally thought to prevent C. albicans colonization.
Purpose of the Study:
- To review the interactions between Candida albicans and mucosal bacteria.
- To highlight how resident bacteria influence C. albicans physiology.
- To explore C. albicans adaptation as a commensal or pathogen.
Main Methods:
- Literature review of scientific articles.
- Analysis of studies on host-microbe interactions.
- Synthesis of current research on C. albicans and bacterial microbiota.
Main Results:
- Recent findings show synergistic relationships between C. albicans and certain bacteria.
- These interactions impact C. albicans' ability to colonize and cause infection.
- Bacterial microbiota significantly affects C. albicans physiology.
Conclusions:
- The relationship between C. albicans and mucosal bacteria is complex, involving both antagonism and synergy.
- Understanding these interactions is vital for addressing mucosal candidiasis.
- Further research is needed to leverage these interactions for therapeutic strategies.
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