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Fungi Enter the Stage of Colon Carcinogenesis

Claire Conche1, Florian R Greten1

  • 1Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt, Germany.

Immunity
|September 21, 2018
PubMed

Insights

Commensal fungi play an underestimated role in colorectal cancer development. Recent studies highlight their significance, challenging the focus solely on intestinal bacteria in cancer pathogenesis.

Area of Science:

  • Microbiology
  • Oncology
  • Gastroenterology

Background:

  • Intestinal bacteria are recognized contributors to colorectal cancer pathogenesis.
  • The role of commensal fungi in colorectal cancer has been largely overlooked.

Purpose of the Study:

  • To highlight the underappreciated role of commensal fungi in colorectal cancer.
  • To draw attention to recent findings on fungal contributions to colorectal cancer.

Main Methods:

  • Review of recent publications in Immunity by Malik et al. (2018) and Wang et al. (2018).

Main Results:

  • Commensal fungi significantly contribute to the pathogenesis of colorectal cancer.
  • These fungal roles are comparable in importance to those of bacteria.

Conclusions:

  • The contribution of commensal fungi to colorectal cancer warrants further investigation.
  • Future research should consider both bacterial and fungal species in colorectal cancer etiology.

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