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Association of high level of hs-CRP with in-stent restenosis: A case-control study

Mojtaba Baktashian1, Sara Saffar Soflaei1, Negin Kosari2

  • 1Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|September 21, 2018
PubMed

Insights

High sensitive C-reactive protein (hs-CRP) is linked to in-stent restenosis (ISR). Elevated hs-CRP levels, along with diabetes and stent type, predict ISR occurrence in patients after coronary stent implantation.

Area of Science:

  • Cardiology
  • Biomarkers
  • Medical Devices

Background:

  • In-stent restenosis (ISR) is a significant complication following coronary stent implantation.
  • Drug-eluting stents have reduced ISR rates, but it remains a clinical challenge.

Purpose of the Study:

  • To investigate the association between patient characteristics, including serum high sensitive C-reactive protein (hs-CRP), and the development of ISR.
  • To identify potential predictors of ISR after coronary stenting.

Main Methods:

  • A case-control study involving 104 patients with ISR and 202 controls without ISR.
  • Collected baseline data via questionnaire and measured serum biomarkers including hs-CRP, fasting blood glucose (FBG), and triglycerides (TG).
  • Statistical analysis performed using SPSS, with p ≤ 0.05 considered significant.

Main Results:

  • Diabetes mellitus, stent type, serum hs-CRP, FBG, and serum TG were significantly associated with ISR.
  • The association between hs-CRP and ISR persisted after adjusting for stent type and diabetes mellitus.
  • Higher hs-CRP levels (≥2.64 mg/dL) were associated with ISR, diabetes mellitus, and serum triglycerides.

Conclusions:

  • Elevated serum hs-CRP levels are significantly associated with the occurrence of in-stent restenosis.
  • hs-CRP may serve as a valuable biomarker for predicting ISR risk in patients undergoing coronary stenting.
Abstract

Keywords:
Bare stentDrug-eluting stentHs-CRPIn-stent restenosis (ISR)

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