Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Buffer Effectiveness02:19

Buffer Effectiveness

55.3K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.3K
Framing Effects03:26

Framing Effects

8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K
Biological Effects of Radiation02:59

Biological Effects of Radiation

18.0K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Tissue Transplantation01:24

Tissue Transplantation

1.0K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.0K
Effects of feedback01:24

Effects of feedback

1.0K
Feedback in control systems plays a critical role in shaping various operational parameters, extending beyond simple error reduction to influence stability, bandwidth, gain, impedance, and sensitivity. Understanding these effects requires examining a basic feedback system characterized by defined input, output, error, and feedback signals.
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...
1.0K
Self-Awareness and Its Effects01:21

Self-Awareness and Its Effects

316
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
316

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Timing Matter? Postoperative Risk and the Optimal Timing for Total Joint Arthroplasty Following COVID-19 Infection.

Arthroplasty today·2026
Same author

Is Inflammatory Arthritis an Absolute Indication for Patellar Resurfacing in Total Knee Arthroplasty?

The Journal of arthroplasty·2026
Same author

Surgeon Experience Influences Posterior Approach Total Hip Arthroplasty Dislocation Risk, But It Is Mitigated by Robotic Assistance.

The Journal of arthroplasty·2026
Same author

The Cementless, Triple-Tapered, Collared Stem Has Minimal Proximal Femoral Stress Shielding at One Year.

The Journal of arthroplasty·2026
Same author

Robotic Unicompartmental Knee Arthroplasty Demonstrates Improved Recovery During the First 90 Postoperative Days Compared With Robotic Total Knee Arthroplasty: A Prospective Remote Monitoring Study.

The Journal of arthroplasty·2026
Same author

Back-to-base Versus In-transit Machine Perfusion in Donation After Circulatory Death Liver Transplantation: Insights From a National Registry.

Transplantation direct·2026

Related Experiment Video

Updated: Feb 5, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.7K

Evaluating meniscus allograft transplant using a cost-effectiveness threshold analysis.

Ilya Bendich1, William Rubenstein1, Mohamed Mustafa Diab2

  • 1Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States of America.

The Knee
|September 21, 2018
PubMed
Summary
This summary is machine-generated.

Meniscal allograft transplant (MAT) must be 31% more effective in delaying osteoarthritis (OA) to be cost-effective compared to non-operative care. Younger, non-obese patients benefit most from MAT for cost-effectiveness.

Keywords:
Cost effectivenessCost-effectiveness analysisMeniscectomyMeniscus allograft transplant

More Related Videos

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
08:30

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

3.2K
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
09:01

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

Published on: July 27, 2022

2.5K

Related Experiment Videos

Last Updated: Feb 5, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.7K
A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
08:30

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

3.2K
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
09:01

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

Published on: July 27, 2022

2.5K

Area of Science:

  • Orthopedic surgery
  • Biomedical engineering
  • Health economics

Background:

  • The impact of meniscal allograft transplant (MAT) on osteoarthritis (OA) progression remains unclear.
  • Cost-effectiveness analysis can determine the necessary delay in OA progression for MAT to be economically viable against non-operative management.
  • This study aims to establish the efficacy threshold for MAT in preventing OA in knees previously treated with meniscectomy.

Purpose of the Study:

  • To determine the cost-effectiveness of meniscal allograft transplant (MAT) versus non-operative management for delaying osteoarthritis (OA) progression.
  • To analyze how patient age and body mass index (BMI) influence the cost-effectiveness of MAT.

Main Methods:

  • A Markov model was employed to compare the cost-effectiveness of MAT against non-operative strategies.
  • Data on input parameters, costs, and OA progression rates were sourced from existing literature and The PearlDiver Patient Records Database.
  • The study compared the required efficacy of MAT in delaying OA progression across different patient profiles.

Main Results:

  • Meniscal allograft transplant (MAT) must demonstrate 31% greater efficacy in delaying OA progression to be cost-effective compared to non-operative interventions.
  • Cost-effectiveness is maximized in younger patients (20-29 years), where MAT requires only a 25% increase in efficacy.
  • Obesity (BMI 30-35) reduces MAT's cost-effectiveness, though the required efficacy increase over non-operative management is approximately 10%.

Conclusions:

  • Meniscal allograft transplant (MAT) requires approximately 33% greater effectiveness in delaying OA in previously meniscectomized knees to be considered cost-effective.
  • Younger, non-obese individuals represent the patient demographic with the lowest required efficacy for MAT to achieve cost-effectiveness.