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Related Experiment Video

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CKD in Patients with Bilateral Oophorectomy.

Andrea G Kattah1, Carin Y Smith2, Liliana Gazzuola Rocca3

  • 1Division of Nephrology and Hypertension, Department of Internal Medicine.

Clinical Journal of the American Society of Nephrology : CJASN
|September 21, 2018
PubMed
Summary

Bilateral oophorectomy before age 50 increases premenopausal women's risk of chronic kidney disease (CKD). The risk is even higher for women undergoing the procedure at age 45 or younger.

Keywords:
Body Mass IndexCohort StudiesEstrogensIncidenceMenopauseMultiple Chronic ConditionsOophorectomyOvariectomyPremenopauseProportional Hazards ModelsRenal Insufficiency, ChronicSmokingaccelerated agingchronic kidney diseasecohort studyestrogenglomerular filtration ratemodifiable risk factor

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Area of Science:

  • Nephrology
  • Endocrinology
  • Reproductive Health

Background:

  • Bilateral oophorectomy in premenopausal women is linked to increased morbidity and mortality.
  • Estrogen plays a role in maintaining kidney function.

Purpose of the Study:

  • To investigate the association between bilateral oophorectomy and the risk of developing chronic kidney disease (CKD).
  • To determine if age at oophorectomy influences CKD risk.

Main Methods:

  • Population-based cohort study matching 1653 women who underwent bilateral oophorectomy before age 50 to 1653 referent women.
  • Follow-up for a median of 14 years to assess CKD incidence, primarily defined by eGFR <60 ml/min/1.73 m² on two occasions.
  • Adjusted analyses for 17 chronic conditions, race, education, BMI, smoking, age, and calendar year using Cox proportional hazards models.

Main Results:

  • Women undergoing bilateral oophorectomy showed a significantly higher risk of eGFR-based CKD (aHR, 1.42; absolute risk increase, 6.6%).
  • The risk of CKD was notably higher in women who underwent oophorectomy at age ≤45 years (aHR, 1.59; absolute risk increase, 7.5%).

Conclusions:

  • Premenopausal bilateral oophorectomy, especially before age 45, elevates the risk of CKD.
  • Findings are robust after adjusting for numerous potential confounders.