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Increased expression of miR-33a in monocytes from Mexican hypertensive patients in elevated carotid intima-media

Yazmín Estela Torres-Paz1, Claudia Huesca-Gómez1, Fausto Sánchez-Muñoz2

  • 1Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", México City, Mexico.

Journal of Human Hypertension
|September 21, 2018
PubMed

Insights

MicroRNA-33a (miR-33a) expression in monocytes is linked to hypertension risk and carotid intima-media thickness. Upregulated miR-33a-5p and downregulated miR-33a-3p in monocytes correlate with hypertension and atherosclerosis markers.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genetics and Genomics

Background:

  • MicroRNA-33a (miR-33a) is recognized for its role in atherosclerosis.
  • The specific involvement of miR-33a in arterial hypertension (HTA) remains underexplored.
  • Understanding miR-33a's function in HTA is crucial for identifying new diagnostic and therapeutic targets.

Purpose of the Study:

  • To investigate the association between miR-33a (both 5p and 3p strands) expression and carotid intima-media thickness (cIMT) in hypertensive patients.
  • To analyze miR-33a expression levels in monocytes and serum of individuals with and without hypertension.
  • To determine if miR-33a expression in monocytes is a risk factor for developing hypertension and associated cardiovascular changes.

Main Methods:

  • Real-time quantitative PCR (RT-PCR) was used to measure miR-33a-5p and miR-33a-3p expression.
  • Samples included monocytes and serum from 42 Mexican patients with essential hypertension and 42 normotensive controls.
  • Statistical analyses, including odds ratios (OR) and confidence intervals (CI), were employed to assess associations.

Main Results:

  • miR-33a-5p was significantly upregulated in monocytes of hypertensive patients (p=0.001).
  • miR-33a-3p was significantly downregulated in monocytes of hypertensive patients (p=0.013).
  • Both miR-33a-5p upregulation and miR-33a-3p downregulation in monocytes were associated with increased hypertension risk (OR=5.53 and OR=3.32, respectively).
  • Upregulation of miR-33a-5p in monocytes correlated with increased cIMT (OR=5.99, p=0.039).
  • No significant differences in miR-33a expression were observed in serum samples.

Conclusions:

  • Monocyte expression of miR-33a-5p and miR-33a-3p is altered in hypertension.
  • These alterations in monocyte miR-33a expression are associated with hypertension risk and cIMT.
  • miR-33a-5p upregulation in monocytes may play a role in atherosclerosis development in hypertensive patients.

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