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Correction: Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause

T Maekawa1, Y Osawa2, T Izumi2

  • 1Division of Hematology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan. dri3011@ndmc.ac.jp.

Leukemia
|September 21, 2018
PubMed

Insights

This study corrects figures in a previous article due to an imprecise anti-myeloproliferative leukemia protein (MPL) antibody. Corrected data for MPL antibody specificity are now available in updated figures and supplemental information.

Area of Science:

  • Biomedical Research
  • Molecular Biology
  • Immunology

Background:

  • The myeloproliferative leukemia protein (MPL) is crucial in hematopoiesis.
  • Antibody specificity is vital for accurate experimental results.
  • Previous findings were potentially impacted by antibody limitations.

Purpose of the Study:

  • To correct inaccuracies in previously published data.
  • To provide accurate figures related to anti-myeloproliferative leukemia protein (MPL) antibody specificity.
  • To ensure the reliability of research findings concerning MPL.

Main Methods:

  • Re-evaluation of experimental data using a more specific anti-MPL antibody.
  • Correction of specific figures (Figure 6, parts of 2a, 4e, 5a).
  • Provision of corrected figures and supplemental data.

Main Results:

  • Identified insufficient specificity of the original anti-MPL antibody.
  • Corrected Figure 6 is provided.
  • Corrected data for Figures 2a, 4e, and 5a are available in supplemental information.

Conclusions:

  • The original figures contained inaccuracies due to antibody limitations.
  • Corrected data ensure the integrity of research on myeloproliferative leukemia protein (MPL).
  • This correction enhances the reliability of studies involving MPL antibody assays.

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