Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis in E. coli01:27

Chemotaxis in E. coli

847
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
847
Stringent Response in E. coli01:23

Stringent Response in E. coli

355
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
355
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

16.2K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
16.2K
Mismatch Repair01:36

Mismatch Repair

43.7K
Overview
43.7K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.9K
Overview
40.9K
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

19.8K
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
19.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Microbiological Quality of Ready-to-Eat Salad and Salad Components Collected from Retail and Catering Premises in England and Northern Ireland.

Journal of food protection·2026
Same author

Acceptability and Feasibility of Longitudinal Sampling for Sexually Transmitted Enteric Infections in Gay, Bisexual, and Other Men Who Have Sex With Men (GBMSM): Prospective Cohort Pilot Study Conducted in 2022 in South East England.

JMIR public health and surveillance·2026
Same author

Mind the gap! Typing <i>Escherichia coli</i> O157:H7 in the pre- and post-genomic revolution eras.

Microbial genomics·2026
Same author

A 5-year review of <i>Helicobacter pylori</i> isolated from gastric biopsies at the UK Health Security Agency Gastrointestinal Bacteria Reference Unit.

Journal of medical microbiology·2026
Same author

The Third Study of Infectious Intestinal Disease (IID3 Study) in the Community: Protocol for UK-Based Prospective Cohort Studies Investigating the Disease Burden.

JMIR research protocols·2026
Same author

Public health surveillance of <i>Vibrio cholerae</i> in travellers returning to the United Kingdom.

Journal of medical microbiology·2026
Same journal

Resolution Failure in Periodontal Diseases: Dysregulated Pro-resolving Mechanisms in Chronic Inflammation and Tissue Breakdown.

Current topics in microbiology and immunology·2026
Same journal

Correction to: Resolution of Skeletal Muscle Inflammation: Role of Specialized Pro-resolving Lipid Mediators in the Recovery from Exercise, Injury, and Disease.

Current topics in microbiology and immunology·2026
Same journal

Resolution Biology in Soft Tissue Joint Disease.

Current topics in microbiology and immunology·2026
Same journal

A 25+ Year Journey on Yeast-Regulated Cell Death Research.

Current topics in microbiology and immunology·2026
Same journal

Adoptive T-Cell Immunotherapy.

Current topics in microbiology and immunology·2026
Same journal

Resolution Pharmacology Targeting the Melanocortin System.

Current topics in microbiology and immunology·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria
09:56

Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria

Published on: October 13, 2021

4.8K

Enteroaggregative Escherichia coli.

Claire Jenkins1

  • 1Public Health England, 61 Colindale Avenue, London, NW9 5HT, UK. claire.jenkins@phe.gov.uk.

Current Topics in Microbiology and Immunology
|September 21, 2018
PubMed
Summary
This summary is machine-generated.

Enteroaggregative Escherichia coli (EAEC) cause diarrhea, especially in children. Understanding EAEC virulence factors and genomic diversity is crucial for public health and disease control.

More Related Videos

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System
14:12

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System

Published on: November 21, 2023

2.6K
The Multifaceted Benefits of Protein Co-expression in Escherichia coli
12:48

The Multifaceted Benefits of Protein Co-expression in Escherichia coli

Published on: February 5, 2015

12.5K

Related Experiment Videos

Last Updated: Feb 5, 2026

Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria
09:56

Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria

Published on: October 13, 2021

4.8K
Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System
14:12

Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System

Published on: November 21, 2023

2.6K
The Multifaceted Benefits of Protein Co-expression in Escherichia coli
12:48

The Multifaceted Benefits of Protein Co-expression in Escherichia coli

Published on: February 5, 2015

12.5K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genomics

Background:

  • Enteroaggregative Escherichia coli (EAEC) are a significant cause of acute and persistent watery diarrhea, particularly in children in low-income settings.
  • EAEC is also linked to traveler's diarrhea and can cause severe, potentially life-threatening illness in vulnerable populations due to specific virulence factors.
  • The pathogen exhibits diverse strains, with not all strains causing disease, and virulence determinants are located on plasmids or chromosomal pathogenicity islands.

Purpose of the Study:

  • To investigate the genomic structure and virulence factors of Enteroaggregative Escherichia coli (EAEC).
  • To understand the mechanisms behind EAEC pathogenesis and its public health implications.
  • To explore the role of horizontal gene transfer in EAEC evolution and adaptation.

Main Methods:

  • Detection of EAEC-associated traits in food and fecal samples.
  • Isolation and confirmation of EAEC using Polymerase Chain Reaction (PCR) for specific genes.
  • Whole-genome sequencing to analyze genomic structure and identify virulence factors.

Main Results:

  • EAEC possesses a mosaic genomic structure, indicating significant horizontal gene transfer and recombination.
  • Virulence factors are encoded on plasmids (plasmid of aggregative adherence) or chromosomal pathogenicity islands.
  • Multidrug resistance is common and widespread in EAEC strains.
  • Evidence suggests foodborne transmission, but no zoonotic reservoir has been identified.

Conclusions:

  • The genomic diversity and plasticity of EAEC, driven by horizontal gene transfer, contribute to its pathogenic potential.
  • Understanding EAEC's virulence mechanisms and transmission routes is vital for effective public health interventions.
  • Molecular screening assays should incorporate chromosomal markers due to plasmid variability.