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Related Experiment Video

Updated: Feb 5, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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Photobiomodulation is associated with a decrease in cell viability and migration in oral squamous cell carcinoma.

Tatiana Dias Schalch1, Maria Helena Fernandes2, Maria Fernanda Setúbal Destro Rodrigues1

  • 1Biophotonics Applied to Health Sciences Postgraduate Program, Nove de Julho University - UNINOVE, 235/249 Vergueiro Street, São Paulo, 01504-001, Brazil.

Lasers in Medical Science
|September 21, 2018
PubMed
Summary

Photobiomodulation (PBM) using specific laser parameters can safely treat oral squamous cell carcinoma (SCC) side effects. This study found that 780 nm laser irradiation reduced tumor cell viability and migration, indicating PBM

Keywords:
Low-level laser therapyMouth neoplasmsMucositisOral squamous carcinoma cellsPhotobiomodulation

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Area of Science:

  • Oncology
  • Biophotonics
  • Cell Biology

Background:

  • Squamous cell carcinoma (SCC) treatments like surgery, chemotherapy, and radiotherapy can cause painful oral mucositis.
  • Photobiomodulation (PBM) is used for mucositis, but its safety on remaining oral SCC tumor cells is questioned.

Purpose of the Study:

  • To evaluate the effects of PBM on oral SCC cell viability, mitochondrial activity, proliferation, apoptosis, and migration.
  • To determine safe PBM parameters for potential use in SCC patients experiencing mucositis.

Main Methods:

  • Oral SCC (SCC9) cells were irradiated with 660 nm and 780 nm lasers using 11 dosimetric parameters.
  • Assays included neutral red, BrdU, scratch-wound, mitochondrial activity, and caspase 3 activity.
  • Experiments were performed in triplicate, comparing irradiated cells to non-irradiated controls.

Main Results:

  • All 11 tested PBM parameters reduced mitochondrial activity and induced apoptosis in SCC cells.
  • PBM parameters recommended for mucositis, specifically 780 nm (70 mW, 4 J/cm²), reduced SCC cell viability.
  • This specific PBM parameter also induced apoptosis and decreased the migratory capacity of oral SCC cells.

Conclusions:

  • PBM, particularly at 780 nm with specific parameters, demonstrates potential for safely treating oral mucositis in SCC patients.
  • This PBM approach may reduce tumor cell viability, induce apoptosis, and inhibit migration, suggesting a dual benefit in SCC management.