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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Noncoding RNAs in Cardiovascular Aging.

Yongqin Li1, Yujiao Zhu1, Guoping Li2

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Advances in Experimental Medicine and Biology
|September 21, 2018
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Summary
This summary is machine-generated.

Noncoding RNAs (ncRNAs) are crucial regulators in cardiovascular aging and cellular senescence. Understanding their roles in the aging cardiovascular system is vital for developing new therapeutic strategies.

Keywords:
Cardiovascular agingLncRNAsMicroRNAsNoncoding RNAsSenescence

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Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Aging Research

Background:

  • The global elderly population is increasing, leading to a higher prevalence of cardiovascular diseases and aging-related pathologies.
  • Cardiovascular aging poses significant economic, societal, and individual burdens, necessitating effective prevention and therapeutic strategies.

Purpose of the Study:

  • To provide an overview of noncoding RNAs (ncRNAs) and their mechanisms in cardiovascular aging.
  • To highlight the role of ncRNAs in cellular senescence and aging within the cardiovascular system.

Main Methods:

  • Literature review and synthesis of existing evidence on ncRNAs in cardiovascular aging.
  • Analysis of the regulatory functions of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in cardiovascular pathophysiology.

Main Results:

  • Noncoding RNAs, including miRNAs and lncRNAs, are key regulators of gene expression implicated in cardiovascular aging.
  • These molecules play significant roles in the pathophysiological processes of cellular senescence and aging in cardiovascular systems.

Conclusions:

  • Noncoding RNAs are critically involved in the mechanisms underlying cardiovascular aging.
  • Further research is essential to fully elucidate the molecular mechanisms of ncRNAs in cardiovascular aging and to develop targeted therapies.