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Updated: Feb 5, 2026
11:39
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
Published on: June 9, 2019
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CE-MS for metabolomics: Developments and applications in the period 2016-2018
Rawi Ramautar1, Govert W Somsen2, Gerhardus J de Jong3
1Biomedical Microscale Analytics, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Electrophoresis
|September 21, 2018
Summary
Capillary electrophoresis-mass spectrometry (CE-MS) is a powerful tool for analyzing polar metabolites in biological samples. Recent advancements focus on improving CE-MS techniques for large-scale metabolic profiling in various research fields.
Area of Science:
- Analytical Chemistry
- Metabolomics
- Biotechnology
Background:
- Capillary electrophoresis-mass spectrometry (CE-MS) is a key technique for analyzing polar and charged metabolites.
- Significant research efforts are directed towards enhancing CE-MS for large-scale metabolic profiling.
- This review follows a 2017 paper, covering advancements from July 2016 to June 2018.
Purpose of the Study:
- To review main advances in CE-MS approaches for metabolomics studies.
- To discuss developments in interfacing and data analysis for improved CE-MS performance.
- To highlight the utility of CE-MS in diverse metabolomics applications.
Main Methods:
- Literature review of CE-MS applications in metabolomics (July 2016 - June 2018).
- Discussion of advancements in CE-MS interfacing and data analysis tools.
- Compilation of a table detailing recent CE-MS-based metabolomics studies.
Main Results:
- Significant improvements in CE-MS interfacing and data analysis tools have been reported.
- CE-MS has demonstrated utility in biomedical, clinical, microbial, and plant metabolomics.
- A comprehensive table summarizes recent CE-MS studies, including sample types and MS detection modes.
Conclusions:
- CE-MS continues to evolve as a vital technique in metabolomics research.
- Ongoing developments promise further expansion of CE-MS applications in metabolic profiling.
- Future perspectives suggest continued innovation in CE-MS methodologies for biological sample analysis.
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