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Updated: Feb 5, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Problem-Solving in Patients with Targeted Drug Delivery Systems
1Rez Farid, MD, is Associate Professor of Clinical PM&R, Department of Physical Medicine and Rehabilitation, University of Missouri Health Care.
Abstract:
Patients with intrathecal drug delivery systems presenting for after-hours care typically cause angst among physicians staffing emergency rooms and urgent care centers. The chief complaint of "my pump isn't working" leaves physicians inexperienced with these devices in a defensive position. Fortunately, pump malfunctions are rare. Resources are available to help physicians work through patient concerns. These resources include algorithms to manage possible over- or under-infusion of the various drugs used in these systems as well as technical support from pump manufacturers.
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