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Updated: Feb 5, 2026

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Surgical embolectomy for acute massive pulmonary embolism: state of the art
Alessandra Iaccarino1,2, Giacomo Frati1,3, Leonardo Schirone1
1Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Abstract:
Massive pulmonary embolism (PE) is a severe condition that can potentially lead to death caused by right ventricular (RV) failure and the consequent cardiogenic shock. Despite the fact thrombolysis is often administrated to critical patients to increase pulmonary perfusion and to reduce RV afterload, surgical treatment represents another valid option in case of failure or contraindications to thrombolytic therapy. Correct risk stratification and multidisciplinary proactive teams are critical factors to dramatically decrease the mortality of this global health burden. In fact, the worldwide incidence of PE is 60-70 per 100,000, with a mortality ranging from 1% for small PE to 65% for massive PE. This review provides an overview of the diagnosis and management of this highly lethal pathology, with a focus on the surgical approaches at the state of the art.
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