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The association between estradiol levels and cognitive function in postmenopausal women
Soheila Gholizadeh1, Shahideh Jahanian Sadatmahalleh1, Saeideh Ziaei1
1Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
International Journal of Reproductive Biomedicine
|September 21, 2018
Summary
Postmenopausal women with lower estradiol levels show impaired cognitive function. Estradiol replacement therapy may be necessary for women experiencing cognitive decline during menopause.
Area of Science:
- Reproductive Endocrinology
- Neuroscience
- Gerontology
Background:
- Estradiol levels naturally decline during menopause, coinciding with increased prevalence of memory dysfunction.
- Cognitive impairment is a significant concern for women transitioning through menopause.
Purpose of the Study:
- To investigate the relationship between endogenous estradiol levels and cognitive function in postmenopausal women.
- To identify potential therapeutic targets for cognitive decline associated with menopause.
Main Methods:
- A cross-sectional study involving 209 healthy postmenopausal women.
- Cognitive function assessed using the Montreal Cognitive Assessment (MoCA) scale.
- Estradiol levels measured and analyzed for association with cognitive scores, adjusted for confounders.
Main Results:
- A high prevalence of cognitive dysfunction (MoCA score ≤26) was observed in 62.7% of participants.
- Significantly lower estradiol levels (14.92±10.24 pg/ml) were found in women with cognitive dysfunction compared to those with normal cognition (21.67±14.92 pg/ml; p<0.001).
- Estradiol levels and educational status were significantly associated with MoCA scores (p<0.001).
Conclusions:
- Low endogenous estradiol levels are significantly associated with cognitive dysfunction in postmenopausal women.
- Estradiol replacement therapy may be a beneficial intervention for postmenopausal women experiencing cognitive decline.
- Further research into hormone replacement therapy for cognitive health in menopause is warranted.
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