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Updated: Feb 5, 2026
09:17
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
22.3K
Risk factors for frontotemporal dementia.
Summary
Modifiable risk factors like diabetes, head trauma, and autoimmune diseases may increase frontotemporal dementia risk. However, more research is needed to establish clinical guidelines for prevention.
Area of Science:
- Neurology
- Neuroscience
- Public Health
Background:
- Frontotemporal dementia (FTD) risk factors are not well understood.
- Identifying modifiable risk factors is crucial for potential prevention strategies.
Purpose of the Study:
- To provide an updated overview of modifiable risk factors for FTD.
- To assess the evidence base for clinical recommendations to reduce FTD risk.
Main Methods:
- A systematic literature search was conducted in PsycInfo, Embase, PubMed, and Cochrane databases (May 2016-April 2017).
- Articles focusing solely on genetic aspects of FTD were excluded.
- 12 relevant review articles and original studies were included after full-text review.
Main Results:
- Some studies indicated a link between modifiable factors and FTD development.
- Diabetes was associated with increased FTD risk in one study.
- Head trauma and autoimmune diseases were linked to increased FTD risk, including primary progressive aphasia.
Conclusions:
- Evidence suggests potential links between diabetes, head trauma, autoimmune diseases, and FTD.
- Current knowledge is insufficient to support population-level lifestyle modification recommendations for FTD prevention.
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