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Related Experiment Video

Updated: Feb 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Recent progress in systemic sclerosis-interstitial lung disease.

Flavia V Castelino¹, Paul F Dellaripa²

¹Division of Rheumatology, Massachusetts General Hospital.

Current Opinion in Rheumatology

|September 21, 2018

Summary

This summary is machine-generated.

Systemic sclerosis patients with interstitial lung disease (ILD) face challenges in predicting progression. Emerging insights and risk models aim to identify high-risk individuals for novel therapies targeting lung fibrosis.

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Area of Science:

Autoimmune diseases
Pulmonary fibrosis
Rheumatology

Background:

Systemic sclerosis is an autoimmune disorder where interstitial lung disease (ILD) is a primary cause of mortality.
Understanding the mechanisms of fibrosis and autoimmunity in lung tissue is crucial for scleroderma treatment.
This review focuses on recent advancements in scleroderma-related ILD.

Purpose of the Study:

To highlight emerging insights into scleroderma-related interstitial lung disease (ILD).
To discuss current and upcoming clinical trials for treating ILD in systemic sclerosis.
To address the challenges in identifying patients at risk for ILD progression.

Main Methods:

Review of current literature on systemic sclerosis and ILD.
Analysis of risk assessment models for ILD progression.
Discussion of ongoing and recent clinical trials for scleroderma ILD.

Main Results:

Challenges remain in identifying patients with progressive ILD in systemic sclerosis.
Risk assessment models incorporating radiographic and physiologic data are being developed.
Novel therapeutic strategies are under investigation for managing lung fibrosis in scleroderma.

Conclusions:

Advancements in risk stratification may enable earlier identification of high-risk patients.
Novel therapies hold promise for limiting the progression of lung disease in systemic sclerosis.
A paradigm shift in managing scleroderma-related ILD is anticipated with ongoing research.