Related Experiment Video
Updated: Feb 5, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Choroidal Detachment and Increased Intraocular Pressure in a Case of Secondary Pulmonary Hypertension
Xunwen Lei1,2,3,4, Jinzhi Zhang2, Qiang Li2
1The First Hospital of Lanzhou University.
Purpose:
To report a case of secondary pulmonary hypertension, choroidal detachment, and increased intraocular pressure (IOP) in a patient with a congenital ventricular septal defect.
Methods:
This is a case report.
Patient:
A 36-year-old man with congenital ventricular septal defect developed dilated and congested conjunctival and episcleral veins, high IOP, and choroidal detachment.
Results:
The right eye had secondary glaucoma, myopia, and choroidal detachment. He had severe pulmonary hypertension and decreased heart function. After successful treatment for heart failure, IOP was reduced, the refractive state returned to normal, choroidal detachment was reversed, and visual acuity improved.
Conclusions:
Secondary pulmonary hypertension resulting from a congenital ventricular septal defect caused serious optic abnormalities that resolved substantially with appropriate treatment of the pulmonary hypertension.
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Hypertension and Regulation of Blood Pressure
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Secondary Active Transport
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

