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FIVE-YEAR FUNCTIONAL OUTCOMES AFTER EPIRETINAL MEMBRANE SURGERY: A Prospective, Controlled Study.

Gowtham Jonna^1,2, Ian A Thompson¹, Thomas A Mendel¹

¹Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee.

Retina (Philadelphia, Pa.)

|September 21, 2018

Summary

Epiretinal membrane (ERM) surgery impacts inner retinal layers, showing progressive ganglion cell-inner plexiform layer (GC-IPL) thinning over 5 years. Visual field function also showed transient worsening after ERM surgery.

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Area of Science:

Ophthalmology
Retinal Surgery
Visual Function Assessment

Background:

Epiretinal membranes (ERMs) can affect visual acuity and cause metamorphopsia.
Understanding long-term functional outcomes after ERM surgery is crucial for patient management.

Purpose of the Study:

To evaluate the 5-year functional outcomes of the inner retina following epiretinal membrane (ERM) surgery.
To assess changes in retinal layer thickness and visual field parameters post-ERM surgery.

Main Methods:

A prospective study involving 20 patients undergoing ERM surgery.
Spectral domain optical coherence tomography (SD-OCT) was used to measure retinal nerve fiber layer and ganglion cell-inner plexiform layer (GC-IPL) thickness.
Humphrey visual field (HVF) testing assessed mean deviation (MD) and pattern standard deviation (PSD) over 60 months.

Main Results:

Surgical eyes (SEs) exhibited progressive GC-IPL thinning compared to fellow eyes (FEs) throughout the 5-year follow-up.
Significant thinning of the superotemporal GC-IPL was observed in SEs at 3 and 60 months (P < 0.05).
HVF mean deviation was transiently worse in SEs compared to FEs at 0, 12, and 24 months (P < 0.05), with increasing pattern SD.

Conclusions:

ERM surgery is associated with progressive inner retinal thinning, specifically GC-IPL loss, over 5 years.
Transient worsening of visual field parameters, including mean deviation and pattern SD, was noted post-ERM surgery.
These findings highlight the long-term structural and functional consequences of ERM surgery on the inner retina.