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Patient-Reported Treatment Satisfaction with Dabigatran versus Warfarin in Patients with Non-Valvular Atrial

Yan-Ping Geng1,2, Di-Hui Lan3, Nian Liu1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.

Thrombosis and Haemostasis
|September 21, 2018
PubMed

Insights

In China, dabigatran for non-valvular atrial fibrillation (NVAF) patients showed no improved satisfaction over warfarin. Higher costs and discontinuation rates were observed with dabigatran, impacting treatment adherence.

Area of Science:

  • Cardiology
  • Pharmacology
  • Health Economics

Background:

  • Patient satisfaction with anticoagulant therapy is crucial for adherence and outcomes in atrial fibrillation.
  • Warfarin has known disadvantages, leading to the exploration of novel oral anticoagulants like dabigatran.

Purpose of the Study:

  • To compare patient-reported treatment satisfaction between dabigatran and warfarin in Chinese non-valvular atrial fibrillation (NVAF) patients.
  • To assess the impact of economic factors and discontinuation rates on treatment choice.

Main Methods:

  • Patient satisfaction was measured using the Anti-Clot Treatment Scale (ACTS) questionnaire.
  • Propensity score matching was used to create comparable groups of 182 dabigatran and warfarin users.
  • Logistic regression analysis identified factors associated with treatment non-persistence.

Main Results:

  • Global ACTS Burdens and Benefits scores were similar between dabigatran and warfarin groups.
  • Dabigatran was significantly more expensive than warfarin due to lack of insurance coverage.
  • Dabigatran had a higher discontinuation rate (33.5% vs. 19.2%) and greater odds of non-persistence.

Conclusions:

  • Dabigatran therapy in Chinese NVAF patients did not improve satisfaction compared to warfarin.
  • Increased economic burden associated with dabigatran led to higher discontinuation rates.
  • Warfarin remains a viable option, considering cost-effectiveness and adherence in this population.
Abstract

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